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SRY (Sex Determining Region Y)-Box 8 (SOX8) (C-Term) antibody

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Antigen
Epitope
C-Term
(33), (11), (10), (8), (5), (5), (5), (5), (2), (1), (1), (1), (1), (1)
Reactivity
Dog (Canine), Human, Mouse (Murine), Rat (Rattus), Xenopus laevis
(86), (21), (19), (1), (1), (1)
Host
Rabbit
(49), (30), (9)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(56), (48), (11), (4), (2), (1), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the C terminal of human SOX8
Sequence ASPTETGPPR PHIKTEQPSP GHYGDQPRGS PDYGSCSGQS SATPAAPAGP
Cross-Reactivity Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
Predicted Reactivity Human : 100 %, Bovine : 90 %, Dog : 90 %, Horse : 90 %, Guinea pig : 80 %, Rat : 80 %, Mouse : 70 %, African clawed frog : 70 %
Purification Affinity Purified
Alternative Name SOX8 (SOX8 Antibody Abstract)
Background SOX8 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. It may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome).This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome).
Molecular Weight 47 kDa
NCBI Accession NM_014587, NP_055402
UniProt P57073
Research Area Neurology
Application Notes WB Suggested Anti-SOX8 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:12500
Positive Control: Hela cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 446 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage 4 °C
Storage Comment Any unfrozen and/or unused material can be stored at 4 °C for short term use (< 1 week), and should not be re-frozen. For longer periods of storage, store at -24 °C
Supplier Images
Western Blotting (WB) image for anti-SRY (Sex Determining Region Y)-Box 8 (SOX8) (C-Term) antibody (ABIN406765) WB Suggested Anti-SOX8 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: ...
Background publications Wissmüller, Kosian, Wolf et al.: "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors." in: Nucleic acids research, Vol. 34, Issue 6, pp. 1735-44, 2006 (PubMed).

Catalog No. ABIN406765
$289.00
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