CD11c antibody (PE)

Catalog No. ABIN4369566

Product Details anti-CD11c Antibody (PE)

Target: CD11c (ITGAX) (Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD11c antibody is conjugated to PE

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Purpose: Mouse monoclonal antibody raised against native ITGAX.

Specificity: This antibody reacts with ITGAX, a 150 KDa integrin expressed mainly on dendritic cells and tissue macrophages.

Cross-Reactivity: Dog, Human, Monkey

Immunogen: Native purified ITGAX from human dendritic cells of synovial fluid.

Clone: BU15

Isotype: IgG1

Application Details

Application Notes: Flow Cytometry (20 µL in human blood cells 100 µL in whole blood or 10⁶ cells in a suspension)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.2 % BSA, 0.09 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.

References for anti-CD11c antibody (PE) (ABIN4369566)

Sadhu, Hendrickson, Dick, Potter, Staunton: "Novel tools for functional analysis of CD11c: activation-specific, activation-independent, and activating antibodies." in: Journal of immunoassay & immunochemistry, Vol. 29, Issue 1, pp. 42-57, (2007) (PubMed).

Myou, Zhu, Boetticher, Qin, Myo, Meliton, Lambertino, Munoz, Hamann, Leff: "Regulation of adhesion of AML14.3D10 cells by surface clustering of beta2-integrin caused by ERK-independent activation of cPLA2." in: Immunology, Vol. 107, Issue 1, pp. 77-85, (2002) (PubMed).

Rezzonico, Imbert, Chicheportiche, Dayer et al.: "Ligation of CD11b and CD11c beta(2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1alpha (MIP-1alpha) and MIP-1beta production in primary human monocytes through a ..." in: Blood, Vol. 97, Issue 10, pp. 2932-40, (2001) (PubMed).

Target Details for CD11c

Target: CD11c (ITGAX) (Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX))

Alternative Name: CD11c / ITGAX (ITGAX Products)

Synonyms: CD11C antibody, SLEB6 antibody, RGD1561123 antibody, AI449405 antibody, Cd11c antibody, Cr4 antibody, N418 antibody, integrin subunit alpha X antibody, integrin alpha X antibody, ITGAX antibody, Itgax antibody

Gene ID: 3687

Pathways: Complement System, Activated T Cell Proliferation, Integrin Complex