Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) antibody (Biotin)

Antigen: Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA)

Synonyms: CD140A, PDGFR2, MGC74795, RHEPDGFRA, PDGFRA

Clonality: Monoclonal (16A1)

Host: Mouse

Reactivity: Human

Conjugate: Biotin

Catalog no.: ABIN457314

Additional Information

Alternative name: CD140a / PDGF-RA

Immunogen: CD140a-transfected NIH 3T3 cells

Isotype: IgG1

Clone: 16A1

Description: CD140a / PDGF-RA (platelet-derived growth factor receptor alpha) is a cell surface receptorfor members of platelet-derived growth factor family, whose intracellular part contains atyrosine kinase domain. CD140a forms homodimers, or heterodimerizes with CD140b /PDGF-RB. Whereas CD140b induces in different cell types their proliferation and migration,the role of CD140a is more controversial, with pro-proliferative or anti-proliferative effects.CD140a has early developmental functions, mediates mesodermal cell migration, and lateracts in signaling associated in epithelial-mesenchymal interactions.

Specificity: The mouse monoclonal antibody 16A1 recognizes CD140a / PDGF-RA, the 170 kDa alphachain of platelet-derived growth factor receptor, which is widely expressed on a variety ofmesenchymal-derived cells and plays pro-proliferative or anti-proliferative roles in varioustumours.HLDA VI., WS Code E022

Application Details

Application Notes: Biotinylated antibody is designed for indirect immunofluorescence analysis by FlowCytometry. Suggested working dilution is 3 µg/ml. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Concentration: 1 mg/ml

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Storage: Store in the dark at 2-8 o C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.Short-term exposure to room temperature should not affect the quality of the reagent.However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user.

Restrictions: For Research Use only