TR4 antibody (pThr184)

Catalog No. ABIN482312

The Rabbit Polyclonal anti-TR4 antibody is suitable to detect TR4 in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for TR4 antibody (pThr184) (ABIN482312)

Target: TR4 (NR2C2) (Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TR4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TR4 Antibody

Binding Specificity: AA 161-210, pThr184

Specificity:

TAK1 (Phospho-Thr184) Antibody detects endogenous levels of TAK1 only when phosphorylated at Thr184.

PhosphorylationH:T184 M:T184 R:T184

Purification: The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human TAK1 around the phosphorylation site of Thr184.

Isotype: IgG

Application Details

Application Notes: WB: 1:500~1:1000 ELISA: 1:1000

Comment:

Unigene-Number: Hs.714773 (NCBI Gene Symbol: MAP3K7)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable at -20°C for at least 1 year.

Expiry Date: 12 months

Target Details for TR4

Target: TR4 (NR2C2) (Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2))

Alternative Name: TAK1

Background:

Synonyms: M3K7, MAP3K7, Mitogen-activated protein kinase kinase kinase 7, TGF-beta- activated kinase 1, Transforming growth factor-beta-activated kinase 1, kinase TAK1

NCBI Gene Symbol: MAP3K7

Molecular Weight: 67 kDa

Gene ID: 6885

OMIM: 602614

UniProt: O43318

Pathways: TCR Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Toll-Like Receptors Cascades