Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (N-Term) antibody

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Antigen
Synonyms RIPK3, RIP3, 2610528K09Rik, AW107945, Rip3, Hcyp2
Epitope
N-Term
(32), (20), (15), (15), (10), (6), (5), (5), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
(121), (33), (13), (6), (6), (4), (2), (1)
Host
Rabbit
(116), (34)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (7), (5), (5), (5), (5), (1)
Application
Western Blotting (WB)
(137), (56), (55), (30), (6), (5), (4), (4), (3), (2), (1), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the N terminal of human RIPK3
Sequence AQHRKWGYDV AVKIVNSKAI SREVKAMASL DNEFVLRLEG VIEKVNWDQD
Predicted Reactivity Human : 100 %, Bovine : 90 %, Pig : 90 %, Rat : 90 %, Horse : 80 %, Mouse : 80 %
Characteristics This is a rabbit polyclonal antibody against RIPK3. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name RIPK3 (RIPK3 Antibody Abstract)
Background RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.
Molecular Weight 57 kDa
Gene ID 11035
NCBI Accession NM_006871, NP_006862
UniProt Q9Y572
Research Area Apoptosis/Necrosis, Signaling
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 518 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (N-Term) antibody (ABIN486988) WB Suggested Anti-RIPK3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
Background publications Cerhan, Ansell, Fredericksen et al.: "Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma." in: Blood, Vol. 110, Issue 13, pp. 4455-63, 2007 (PubMed).

Catalog No. ABIN486988
$289.00
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