Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (N-Term) antibody

Details for Product No. ABIN486988
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Antigen
Synonyms RIP3, Hcyp2, 2610528K09Rik, AW107945, Rip3, RIPK3
Epitope
N-Term
(15), (12), (9), (7), (5), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Rat (Rattus), Mouse (Murine), Cow (Bovine), Human
(79), (31), (19), (14), (14), (12), (12), (3)
Host
Rabbit
(91), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (6), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(83), (48), (35), (24), (10), (8), (6), (2), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN486988
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic peptide directed towards the N terminal of human RIPK3
Sequence AQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLEG VIEKVNWDQD
Predicted Reactivity Human : 100 %, Bovine : 90 %, Pig : 90 %, Rat : 90 %, Horse : 80 %, Mouse : 80 %
Characteristics This is a rabbit polyclonal antibody against RIPK3. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name RIPK3
Background RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.
Molecular Weight 57 kDa
Gene ID 11035
NCBI Accession NM_006871, NP_006862
UniProt Q9Y572
Research Area Apoptosis/Necrosis, Signaling
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 518 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (N-Term) antibody WB Suggested Anti-RIPK3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: 721_B cell lysate
Background publications Cerhan, Ansell, Fredericksen et al.: "Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma." in: Blood, Vol. 110, Issue 13, pp. 4455-63, 2007 (PubMed).

Hosts (91), (7)
Reactivities (79), (31), (19), (14), (14), (12), (12), (3)
Applications (83), (48), (35), (24), (10), (8), (6), (2), (1), (1)
Conjugates (6), (6), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (15), (12), (9), (7), (5), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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