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T-Box 3 (TBX3) (Middle Region) antibody

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Antigen
Synonyms xtbx3, ums, xhl, tbx3-iso, TBX3, TBX3-ISO, UMS, XHL, D5Ertd189e
Epitope
Middle Region
(24), (17), (16), (12), (7), (7), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(82), (32), (29), (3), (2), (1), (1), (1), (1)
Host
Rabbit
(82), (12), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (5), (2), (2), (2), (2), (2)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(83), (56), (9), (9), (6), (6), (4), (3), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the middle region of human TBX3
Blocking Peptide Blocking peptide for this product available: ABIN984844
Sequence VGTSNLKDLC PSEGESDAEA ESKEEHGPEA CDAAKISTTT SEEPCRDKGS
Predicted Reactivity Horse : 100 %, Human : 100 %, Pig : 100 %, Rabbit : 100 %, Bovine : 90 %, Dog : 90 %, Mouse : 90 %, Rat : 90 %, Guinea pig : 90 %
Characteristics This is a rabbit polyclonal antibody against TBX3. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name TBX3 (TBX3 Antibody Abstract)
Background TBX3 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms, however, the full length nature of one variant has not been determined.This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms, however, the full length nature of one variant has not been determined.
Molecular Weight 79 kDa
Gene ID 6926
NCBI Accession NM_016569, NP_057653
UniProt O15119
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 743 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-T-Box 3 (TBX3) (Middle Region) antibody (ABIN487066) WB Suggested Anti-TBX3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: ...
Background publications Yarosh, Barrientos, Esmailpour et al.: "TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylases." in: Cancer research, Vol. 68, Issue 3, pp. 693-9, 2008 (PubMed).

Catalog No. ABIN487066
$289.00
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