TBX3 antibody (Middle Region)

Catalog No. ABIN2777925

Product Details anti-TBX3 Antibody

Target: TBX3 (T-Box 3 (TBX3))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TBX3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: CRDKGSPAVK AHLFAAERPR DSGRLDKASP DSRHSPATIS SSTRGLGAEE

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against TBX3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TBX3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 600 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-TBX3 antibody (ABIN2777925)

Bozyk, Popova, Bentley, Goldsmith, Linn, Weiss, Hershenson: "Mesenchymal stromal cells from neonatal tracheal aspirates demonstrate a pattern of lung-specific gene expression." in: Stem cells and development, Vol. 20, Issue 11, pp. 1995-2007, (2011) (PubMed).

Yano, Yamazaki, Adachi, Okawa, Fort, Uji, Tsukita, Tsukita: "Tara up-regulates E-cadherin transcription by binding to the Trio RhoGEF and inhibiting Rac signaling." in: The Journal of cell biology, Vol. 193, Issue 2, pp. 319-32, (2011) (PubMed).

Target Details for TBX3

Target: TBX3 (T-Box 3 (TBX3))

Alternative Name: TBX3 (TBX3 Products)

Synonyms: xtbx3 antibody, ums antibody, xhl antibody, tbx3-iso antibody, TBX3 antibody, TBX3-ISO antibody, UMS antibody, XHL antibody, D5Ertd189e antibody, T-box 3 antibody, T-box 3 S homeolog antibody, TBX3 antibody, tbx3.S antibody, tbx3 antibody, Tbx3 antibody

Background: TBX3 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms, however, the full length nature of one variant has not been determined.
Alias Symbols: UMS, XHL, TBX3-ISO
Protein Interaction Partner: CA8, AES, SOX2, Dlg4, ELAVL1, HDAC5, HDAC3, HDAC2, HDAC1, TOLLIP, TBX3,
Protein Size: 600

Molecular Weight: 66 kDa

Gene ID: 6926

Pathways: Hormone Transport, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development