PCSK1 antibody (Middle Region)
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- Target See all PCSK1 Antibodies
- PCSK1 (Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1))
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Binding Specificity
- Middle Region
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Reactivity
- Rat, Human, Mouse, Guinea Pig, Horse, Rabbit, Cow, Dog
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PCSK1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- QSPKKSPSAK LNIPYENFYE ALEKLNKPSQ LKDSEDSLYN DYVDVFYNTK
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 79%, Rabbit: 93%, Rat: 93%
- Characteristics
- This is a rabbit polyclonal antibody against PCSK1. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human PCSK1
- Top Product
- Discover our top product PCSK1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 753 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- PCSK1 (Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1))
- Alternative Name
- PCSK1 (PCSK1 Products)
- Synonyms
- BMIQ12 antibody, NEC1 antibody, PC1 antibody, PC3 antibody, SPC3 antibody, Nec-1 antibody, Nec1 antibody, Phpp-1 antibody, BDP antibody, PC1/3 antibody, proprotein convertase subtilisin/kexin type 1 antibody, prohormone convertase 1 antibody, PCSK1 antibody, Pcsk1 antibody, pcsk1 antibody, PC1B antibody
- Background
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PCSK1 is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin.The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. The use of alternate polyadenylation sites has been found for this gene. Multiple alternatively spliced transcript variants have been described for this gene but their full length nature is not known. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: NEC1, PC1, PC3, SPC3, BMIQ12
Protein Interaction Partner: env, AFF1, PCSK1N, REN, PMCH, IAPP, PTK2, CTNNB1,
Protein Size: 753 - Molecular Weight
- 71 kDa
- Gene ID
- 5122
- NCBI Accession
- NM_000439, NP_000430
- UniProt
- P29120
- Pathways
- Peptide Hormone Metabolism
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