GABRB3 antibody (Internal Region)

Catalog No. ABIN488000

The Goat Polyclonal anti-GABRB3 antibody is suitable to detect GABRB3 in samples from Human, Rat, Mouse, Cow and Dog. It has been validated for IHC (p) and EIA.

Quick Overview for GABRB3 antibody (Internal Region) (ABIN488000)

Target: GABRB3 (gamma-aminobutyric Acid (GABA) A Receptor, beta 3 (GABRB3))

Reactivity: Human, Rat, Mouse, Cow, Dog

Host: Goat

Clonality: Polyclonal

Conjugate: This GABRB3 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-GABRB3 Antibody

Binding Specificity: Internal Region

Specificity: This antibody reacts to GABRB3.

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat, Canine, Bovine.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogen: Peptide with sequence C-EKTAKAKNDRSK, from the internal region of the protein sequence according to NP_000805.1, NP_068712.1.

Application Details

Application Notes: Peptide ELISA: 1/8000. Immunohistochemistry on paraffin sections: Human Cortex shows patchy staining near orat the neuronal cell membrane. Recommended concentration: 2-4 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for GABRB3

Target: GABRB3 (gamma-aminobutyric Acid (GABA) A Receptor, beta 3 (GABRB3))

Alternative Name: GABRB3

Background: GABA A Receptor beta 3 is one of at least 13 distinct subunits of a multisubunit chloride channel that serves as the receptor for gamma-aminobutyric acid, the major inhibitory transmitter of the nervous system. The GABAA receptor complex is the molecular target of the benzodiazepine class of tranquilizer drugs, and hence it is also often referred to as the 'benzodiazepine receptor'. The GABAA receptor complex also appears to have distinct binding sites for a variety of other pharmaco-active compounds.Synonyms: GABA A receptor subunit beta-3, GABRB-3, Gamma-aminobutyric acid receptor subunit beta-3

Gene ID: 2562

NCBI Accession: NP_000805

UniProt: P28472

Pathways: Sensory Perception of Sound