BIM antibody (AA 2-198)

Catalog No. ABIN492531

The Mouse Monoclonal anti-BIM antibody (Clone 1C2C8) (ABIN492531) specifically detects BIM in WB, IF and EIA. The antibody is reactive with Human and Mouse samples.

Quick Overview for BIM antibody (AA 2-198) (ABIN492531)

Target: BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This BIM antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Clone: 1C2C8

Product Details anti-BIM Antibody

Binding Specificity: AA 2-198

Specificity: Recognizes Bcl-2-like 11/Bim (2-198).

Characteristics: Synonyms: Bcl2-L-11, BCL2L11, BIM, BimEL, BimL, BimS, Bcl2-interacting mediator of cell death

Purification: Immunoaffinity Chromotography.

Immunogen: A recombinant protein corresponding to amino acids 2 to 198 of Human Bim (NP_619527).

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: Bim antibody can be used for detection of Bim at 0.5-1 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for BIM

Target: BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))

Background: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. Bim is another BH3 domain containing protein which can induce apoptosis. Bim interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.Synonyms: BCL2L11, BIM, Bcl2-L-11, Bcl2-interacting mediator of cell death, BimEL, BimL, BimS

Gene ID: 10018

UniProt: O43521

Pathways: PI3K-Akt Signaling, Neurotrophin Signaling Pathway, Tube Formation, Positive Regulation of Endopeptidase Activity