LY96 antibody (AA 2-160)

Catalog No. ABIN492534

Product Details anti-LY96 Antibody

Target: LY96 (Lymphocyte Antigen 96 (LY96))

Binding Specificity: AA 2-160

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This LY96 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Characteristics: Synonyms: Lymphocyte antigen 96, ESOP-1, LY96, ESOP1, MD2

Purification: Immunoaffinity Chromotography.

Immunogen: A recombinant protein corresponding to amino acids 2 to 160 of Human MD-2 (NP_056179).

Clone: 1A2E3

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: MD2 antibody can be used for detection of MD2 at 0.5-1 μg/mL. Immunohistochemistry: 2.5 μg/mL
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for LY96

Target: LY96 (Lymphocyte Antigen 96 (LY96))

Alternative Name: MD-2 (LY96 Products)

Synonyms: MD2 antibody, ESOP-1 antibody, MD-2 antibody, ly-96 antibody, Ly-96 antibody, Md2 antibody, lymphocyte antigen 96 antibody, LY96 antibody, Ly96 antibody

Background: MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2, e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.Synonyms: ESOP-1, ESOP1, LY96, Lymphocyte antigen 96, MD2

UniProt: Q9Y6Y9

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades