PD-1 antibody

Catalog No. ABIN492541

Product Details anti-PD-1 Antibody

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This PD-1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: Recognizes CD279/PD1.

Characteristics: Synonyms: Protein PD-1, hPD-1, PDCD1, Programmed cell death protein 1

Purification: Immunoaffinity Chromatography.

Immunogen: A ~150 amino acid recombinant protein from Mouse PD-1 (GenBank accession No. NP_032824).

Clone: 7A11B1

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: PD1 antibody can be used for detection of PD1 at 1-2 μg/mL. Positive Control: A-20 cell lysate. Immunohistochemistry: 2.5 μg/mL. Positive Control: Mouse brain tissue.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for PD-1

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Alternative Name: CD279 / PD1 (PDCD1 Products)

Synonyms: CD279 antibody, PD-1 antibody, PD1 antibody, SLEB2 antibody, hPD-1 antibody, hPD-l antibody, Ly101 antibody, Pdc1 antibody, programmed cell death 1 antibody, PDCD1 antibody, Pdcd1 antibody

Background: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of Synonyms: PDCD1, Programmed cell death protein 1, Protein PD-1, hPD-1

Gene ID: 18566

UniProt: Q02242

Pathways: Cancer Immune Checkpoints