MON1A antibody (Internal Region)

Catalog No. ABIN498066

Product Details anti-MON1A Antibody

Target: MON1A (MON1 Homolog A (MON1A))

Binding Specificity: AA 589-601, Internal Region

Reactivity: Human, Mouse, Rat, Cow, Dog

Host: Goat

Clonality: Polyclonal

Conjugate: This MON1A antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: C-RPLKTIYYTG PNE

Specificity: This antibody is expected to recognize isoforms a and b (NP_115731.2, NP_001135973.1).

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat, Canine (Dog), Bovine.
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_115731.2, NP_001135973.1. Genename: MON1A

Application Details

Application Notes: Peptide ELISA: Detection Limit: 1/8000. Western blot: 1-3 μg/mL. Detects a band of Approx 50 kDa in lysates of cell line Jurkat.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for MON1A

Target: MON1A (MON1 Homolog A (MON1A))

Alternative Name: MON1A (MON1A Products)

Synonyms: zgc:162873 antibody, 2810468K17Rik antibody, RGD1308823 antibody, SAND1 antibody, MON1 homolog A, secretory trafficking associated antibody, MON1 secretory trafficking family member A antibody, MON1 homolog A, secretory traffciking associated antibody, MON1A antibody, mon1a antibody, Mon1a antibody

Background: MON1A also known as SAND1, is a 555 amino acid protein that exists as multiple alternatively spliced isoforms and plays an important role in membrane trafficking, specifically through the secretory apparatus. The gene encoding MON1A maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene clusterand a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.Synonyms: SAND1, Vacuolar fusion protein MON1 homolog A

Gene ID: 84315

NCBI Accession: NP_001135973

UniProt: Q86VX9

Pathways: Transition Metal Ion Homeostasis