LMX1B antibody
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- Target See all LMX1B Antibodies
- LMX1B (LIM Homeobox Transcription Factor 1, beta (LMX1B))
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This LMX1B antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificity
- This antibody detects endogenous levels of LMX1B protein. (region surrounding Asp159)
- Cross-Reactivity (Details)
- Species reactivity (tested):Human, Mouse.
- Purification
- Affinity chromatography
- Purity
- > 95 % by SDS-PAGE
- Top Product
- Discover our top product LMX1B Primary Antibody
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- Application Notes
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Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1,0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- LMX1B (LIM Homeobox Transcription Factor 1, beta (LMX1B))
- Alternative Name
- LMX1B (LMX1B Products)
- Synonyms
- LMX1.2 antibody, NPS1 antibody, LMX antibody, LMX1 antibody, LMX1.1 antibody, lmx1b antibody, lmx1b.1 antibody, Xlmx1b antibody, lmx1b.2 antibody, LIM homeobox transcription factor 1 beta antibody, LIM homeobox transcription factor 1, beta b antibody, LIM homeobox transcription factor 1, beta, gene 1 S homeolog antibody, LIM homeobox transcription factor 1, beta a antibody, LMX1B antibody, Lmx1b antibody, lmx1bb antibody, lmx1b.1.S antibody, lmx1ba antibody
- Background
- The Lim class homeobox gene Lmx1b is required for the normal development of the dopaminergic system. Loss of dopaminergic neurons is associated with one of the most prominent human neurological disorders, Parkinson's disease (PD). Dopaminergic neurons play an important role in the control of multiple brain functions including voluntary movement alongside an array of behavioral processes such as mood, reward, addiction, and stress. Lmx1b is one of several transcription factors involved in the generation of dopaminergic neurons in the brain.Synonyms: LIM homeobox transcription factor 1-beta, LIM/homeobox protein 1.2, LIM/homeobox protein LMX1B, LMX-1.2, LMX1B
- Molecular Weight
- approx. 42 kDa
- Gene ID
- 4010
- NCBI Accession
- NP_002307
- UniProt
- O60663
- Pathways
- Dopaminergic Neurogenesis
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