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DOCK1 antibody

DOCK1 Reactivity: Human, Mouse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499057
  • Target See all DOCK1 Antibodies
    DOCK1 (Dedicator of Cytokinesis 1 (DOCK1))
    Reactivity
    • 30
    • 22
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 42
    • 1
    • 1
    • 1
    Rabbit
    Clonality
    • 44
    • 1
    Polyclonal
    Conjugate
    • 18
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DOCK1 antibody is un-conjugated
    Application
    • 15
    • 13
    • 13
    • 13
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Specificity
    This antibody detects endogenous levels of DOCK 180 protein. (region surrounding Lys1692)
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, Mouse.
    Purification
    Affinity chromatography
    Purity
    > 95 % by SDS-PAGE
    Top Product
    Discover our top product DOCK1 Primary Antibody
  • Application Notes
    Western Blot: 1/500 - 1/1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1,0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    DOCK1 (Dedicator of Cytokinesis 1 (DOCK1))
    Alternative Name
    DOCK1 / DOCK180 (DOCK1 Products)
    Synonyms
    DOCK180 antibody, ced5 antibody, 9130006G06Rik antibody, AI854900 antibody, D630004B07Rik antibody, RGD1566072 antibody, dedicator of cytokinesis 1 antibody, dedicator of cytokinesis protein 1 antibody, dedicator of cyto-kinesis 1 antibody, DOCK1 antibody, Dock1 antibody, dock1 antibody, CpipJ_CPIJ002759 antibody
    Background
    The v-Crk oncogene product shares homologous amino acid sequences, designated Src homology region 2 (SH2) and SH3, with many molecules involved in signal transduction. The v-Crk cellular homolog, c-Crk, is a member of a newly emerging class of genes including Nck and GRB2/ASH which encode proteins that consist primarily of SH2 and SH3 domains. Two distinct human c-Crk cDNAs, designated Crk I and Crk II, have been identified and shown to represent alternative splice products of c-Crk. The major translational product of c-Crk I has been identified as a 28 kDa variably expressed protein, while c-Crk II encodes a widely expressed 40 kDa protein and a more variably expressed 42 kDa protein. The major c-Crk transforming activity appears associated with c-Crk I p28 expression. DOCK 180, a 180 kDa protein downstream of Crk, has been identified as a major Crk-associated protein. When DOCK 180 is recruited to the plasma membrane from a cytoplasmic reservoir, presumably by Crk, changes in cellular morphology and spindle formation occur, suggesting DOCK 180 to be a Crk effector molecule.Synonyms: 180 kDa protein downstream of CRK, Dedicator of cytokinesis protein 1
    Molecular Weight
    approx. 215 kDa
    Gene ID
    1793
    NCBI Accession
    NP_001371
    UniProt
    Q14185
    Pathways
    Signaling of Hepatocyte Growth Factor Receptor
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