GRIN2D antibody

Catalog No. ABIN499079

Product Details anti-GRIN2D Antibody

Target: GRIN2D (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2D (GRIN2D))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRIN2D antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects endogenous levels of NMDAε4 protein. (region surrounding Pro706)

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: Western blot: 1: 500 - 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for GRIN2D

Target: GRIN2D (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2D (GRIN2D))

Alternative Name: NMDAR2D (GRIN2D Products)

Synonyms: nr2d antibody, EB11 antibody, GluN2D antibody, NMDAR2D antibody, NR2D antibody, glutamate ionotropic receptor NMDA type subunit 2D antibody, glutamate receptor, ionotropic, N-methyl D-aspartate 2D antibody, glutamate receptor, ionotropic, N-methyl D-aspartate 2D L homeolog antibody, glutamate receptor, ionotropic, NMDA2D (epsilon 4) antibody, GRIN2D antibody, grin2d.L antibody, grin2d antibody, Grin2d antibody

Background: Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration . Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, caution-specific ion channels . Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7 . The kainate/AMPA receptors are primarily responsible for the fast excitatory neurotransmission by glutamate whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions . The NMDA receptors consist of five subunits: epsilion 1, 2, 3, 4 and one zeta subunit . The zeta subunit is expressed throughout the brainstem, whereas the four epsilon subunits display limited distribution.Synonyms: GRIN2D, Glutamate [NMDA] receptor subunit epsilon-4, N-methyl D-aspartate receptor subtype 2D, NMDAR2D, NR2D

Molecular Weight: approx. 170 kDa

Gene ID: 2906

NCBI Accession: NP_000827

UniProt: O15399

Pathways: Synaptic Membrane