GRIN2D antibody (Internal Region)

Catalog No. ABIN6258225

Product Details anti-GRIN2D Antibody

Target: GRIN2D (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2D (GRIN2D))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRIN2D antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificity: GRIN2D Antibody detects endogenous levels of total GRIN2D.

Predicted Reactivity: Pig,Bovine,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human GRIN2D, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for GRIN2D

Target: GRIN2D (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2D (GRIN2D))

Alternative Name: GRIN2D (GRIN2D Products)

Synonyms: nr2d antibody, EB11 antibody, GluN2D antibody, NMDAR2D antibody, NR2D antibody, glutamate ionotropic receptor NMDA type subunit 2D antibody, glutamate receptor, ionotropic, N-methyl D-aspartate 2D antibody, glutamate receptor, ionotropic, N-methyl D-aspartate 2D L homeolog antibody, glutamate receptor, ionotropic, NMDA2D (epsilon 4) antibody, GRIN2D antibody, grin2d.L antibody, grin2d antibody, Grin2d antibody

Background:

Description: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+ (PubMed:9489750, PubMed:27616483, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:9489750).

Gene: GRIN2D

Molecular Weight: 170 kDa

Gene ID: 2906

UniProt: O15399

Pathways: Synaptic Membrane