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Details for Product No. ABIN499201

Apoptotic Chromatin Condensation Inducer 1 (ACIN1) (Intermediate Domain) antibody

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Antigen
Synonyms
ACINUS, ACN, fSAP152, Acn, Acinus, C79325, acinusL, acinusS, mKIAA0670, 2610036I19Rik, 2610510L13Rik, acinus, acinusb, fi14c05, wu:fe06a10, wu:fi14c05, acinusa, acinusl, wu:fb04g06, wu:fb40f03, wu:fb6 ... show more
Epitope
»Alternatives Intermediate Domain
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN499201
Quantity 0.1 mg
Price
390.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Human Acinus (Intermediate Domain) Peptide (AP30012CP-N)
Isotype IgG
Specificity Acinus antibody was raised against a peptide corresponding to amino acids 775 to 789 of Human AcinusL, 48 to 62 of human AcinusS’, or 17 to 31 of human AcinusS, which differ from those of mouse Acinus by one amino acid .
Purification Affinity chromatography purified via peptide column
Alternative Name Acinus / ACIN1
Background Chromatin condensation and nuclear fragmentation (CCNF) is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE . A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS (2).
Alternate names: Apoptotic chromatin condensation inducer in the nucleus, KIAA0670
Gene ID 22985
NCBI Accession AAD56724
UniProt Q9UKV3
Research Area Cell Cycle, Apoptosis/Necrosis
Application Notes ELISA. Western Blot: Acinus antibody can be used for detection of Acinus at 0.5 to 1 μg/ml. A 220kDa band can be detected. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Zamzami, Kroemer: "Condensed matter in cell death." in: Nature, Vol. 401, Issue 6749, pp. 127-8, 1999 (PubMed).

Sahara, Aoto, Eguchi et al.: "Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation." in: Nature, Vol. 401, Issue 6749, pp. 168-73, 1999 (PubMed).

Alternatives for antigen "Apoptotic Chromatin Condensation Inducer 1 (ACIN1)", type "Antibodies"
Hosts (131), (6)
Reactivities (130), (40), (25), (24), (24), (12)
Applications (115), (40), (34), (20), (12), (12), (8), (3), (2), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (35), (19), (12), (4), (4), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1)
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