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B-Cell Receptor-Associated Protein 31 (BCAP31) (C-Term) antibody

Details for Product No. ABIN499417
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Antigen
Synonyms 6c6-ag, bap31, cdm, dxs1357e, BCAP31, Bap31, 6C6-AG, BAP31, CDM, DXS1357E, CALD1, caldesmon, si:bz30i22.4, si:rp71-30i22.4, zgc:56389
Epitope
C-Term
(21), (9), (5), (5), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(103), (56), (54), (22), (19), (17), (4), (3), (1), (1)
Host
Rabbit
(85), (8), (7), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(89), (46), (26), (23), (14), (9), (8), (8), (6), (5), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN499417
401.50 $
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Immunogen Human BAP31 (C-Terminus) Peptide (AP30123CP-N)
Isotype IgG
Specificity BAP31 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human BAP31.
Purification Affinity chromatography purified via peptide column
Alternative Name BCAP31 / BAP31
Background Bap31 and the related protein Bap29 are endoplasmic reticulum (ER) and ER-vesicle membrane proteins and members of the B-cell receptor-associated protein family (1,2). These two proteins are highly homologous and can form homo- and heterodimers. Bap31 is thought to be involved in the intracellular trafficking of several molecules such as MHC Class I molecules and CD11b/CD18 (3,4). It may also play a role in the initiation of ER stress- induced apoptosis through its association with caspase-8 via a death effector domain in its cytoplasmic tail, possibly through the promotion of membrane fragmentation and the release of cytochrome c from mitochondria (5). Bap31 itself contains two caspase cleavage sites and is cleaved during apoptosis. The p20 fragment of Bap31, when expressed ectopicially, is also a potent inducer cell death (5).
Alternate names: 6C6-AG tumor-associated antigen, B-cell receptor-associated protein 31, BCR-associated protein Bap31, DXS1357E, Protein CDM, p28 Bap31
Gene ID 10134
NCBI Accession NP_005736
UniProt P51572
Application Notes ELISA. Western Blot. BAP31 antibody can be used for the detection of BAP31 at 0.5 – 1 μg/ml. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Kim, Adachi, Nielsen et al.: "Two new proteins preferentially associated with membrane immunoglobulin D." in: The EMBO journal, Vol. 13, Issue 16, pp. 3793-800, 1994 (PubMed).

Ng, Nguyen, Kwan et al.: "p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum." in: The Journal of cell biology, Vol. 139, Issue 2, pp. 327-38, 1997 (PubMed).

Paquet, Cohen-Doyle, Shore et al.: "Bap29/31 influences the intracellular traffic of MHC class I molecules." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 12, pp. 7548-55, 2004 (PubMed).

Zen, Utech, Liu et al.: "Association of BAP31 with CD11b/CD18. Potential role in intracellular trafficking of CD11b/CD18 in neutrophils." in: The Journal of biological chemistry, Vol. 279, Issue 43, pp. 44924-30, 2004 (PubMed).

Kojić, Reljin, Reljin: "A neural networks-based hybrid routing protocol for wireless mesh networks." in: Sensors (Basel, Switzerland), Vol. 12, Issue 6, pp. 7548-75, 2012 (PubMed).

Validation Images
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