BST2 antibody (N-Term)

Catalog No. ABIN499505

Product Details anti-BST2 Antibody

Target: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Binding Specificity: N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BST2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to Bst2.

Purification: Affinity chromatography purified via peptide column

Immunogen: Bst2 antibody was raised against a 18 amino acid peptide near the amino terminus of the mouse Bst2.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: Bst2 antibody can be used for detection of Bst2 at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for BST2

Target: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Alternative Name: CD317 / BST2 (BST2 Products)

Synonyms: BST2 antibody, CD317 antibody, TETHERIN antibody, 2310015I10Rik antibody, Bst-2 antibody, C87040 antibody, DAMP-1 antibody, GREG antibody, Damp1 antibody, bone marrow stromal cell antigen 2 antibody, bone marrow stromal antigen 2 antibody, BST2 antibody, LOC618737 antibody, Bst2 antibody

Background: Bst2 was first identified as a novel terminal B-cell-restricted antigen termed HM1.24 that is expressed on certain bone marrow cells as well as other tissues. The surface expression of Bst2 on fibroblast cell lines facilitated the stromal cell-dependent growth of DW34, a pre-B-cell line, suggesting that this protein is involved in pre-B-cell growth. Later experiments also showed it to be upregulated in several myeloma cells. More recently, Bst2 was identified an inhibitor of retroviral release from human cells whose activity is antagonized by the HIV-1 accessory protein Vpu. While Bst2 caused retention of virions on cell surfaces or endocytosis into Bst2-positive compartments, its depletion abolished the viral requirement for Vpu for virus release. This activity may represent a potential therapeutic strategy for the treatment of HIV/AIDS.Synonyms: BST-2, Bone marrow stromal antigen 2, HM1.24 antigen, Tetherin

Gene ID: 69550

UniProt: Q8R2Q8

Pathways: Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response