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Details for Product No. ABIN499561

Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (N-Term) antibody

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Antigen
Synonyms TX, ICH-2, Mih1/TX, ICEREL-II, ICE(rel)II, Casp11, Caspl, ich-3, CASP4
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN499561
Quantity 0.1 mg
Price
390.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Human Casp-4 / ICH-2 / ICE rel II / Mih1 (N-Terminus) Peptide (AP30197CP-N)
Isotype IgG
Specificity This antibody was raised against a 16 amino acid peptide from the amino-terminus of human Caspase-4.
Purification Affinity chromatography purified via peptide column
Alternative Name Caspase-4
Background Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1). Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1beta and IL-18 (2,3). Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells (4). More recent studies have shown that it can be activated by ER stress and has been suggested to be involved in multiple neuronal pathologies such as Alzheimer’s disease (5).
Alternate names: CASP4, ICE(rel)-II, ICH2, Protease ICH-2, Protease TX
Gene ID 837
NCBI Accession AAA86890
UniProt P49662
Research Area Apoptosis/Necrosis
Application Notes ELISA. Western Blot: Casp-4 antibody can be used for the detection of Caspase-4 at 1 μg/ml. Depending on cell lines or tissues used, other cleavage products may be observed. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, 0.02% Sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Kuida, Lippke, Ku et al.: "Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme." in: Science (New York, N.Y.), Vol. 267, Issue 5206, pp. 2000-3, 1995 (PubMed).

Kamens, Paskind, Hugunin et al.: "Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases." in: The Journal of biological chemistry, Vol. 270, Issue 25, pp. 15250-6, 1995 (PubMed).

Gracie, Robertson, McInnes: "Interleukin-18." in: Journal of leukocyte biology, Vol. 73, Issue 2, pp. 213-24, 2003 (PubMed).

Martinon, Tschopp: "Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases." in: Cell, Vol. 117, Issue 5, pp. 561-74, 2004 (PubMed).

Alternatives for antigen "Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4)", type "Antibodies"
Hosts (112), (11), (9), (6), (6)
Reactivities (103), (60), (34), (12), (5), (2)
Applications (122), (46), (39), (30), (19), (10), (6), (5), (3), (3), (3), (1), (1)
Conjugates (8), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (24), (12), (8), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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