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COPS8 antibody (C-Term)

COPS8 Reactivity: Human, Rat, Mouse WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499656
  • Target See all COPS8 Antibodies
    COPS8 (COP9 Signalosome Subunit 8 (COPS8))
    Binding Specificity
    • 15
    • 9
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    C-Term
    Reactivity
    • 48
    • 22
    • 21
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Rat, Mouse
    Host
    • 43
    • 5
    Rabbit
    Clonality
    • 46
    • 2
    Polyclonal
    Conjugate
    • 20
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This COPS8 antibody is un-conjugated
    Application
    • 42
    • 20
    • 13
    • 6
    • 5
    • 5
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts to CSN8.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    CSN8 antibody was raised against a 15 amino acid peptide near the carboxy terminus of the human CSN8.
    Isotype
    IgG
    Top Product
    Discover our top product COPS8 Primary Antibody
  • Application Notes
    ELISA. Western Blot: CSN8 antibody can be used for detection of CSN8 at 1 - 2 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    COPS8 (COP9 Signalosome Subunit 8 (COPS8))
    Alternative Name
    COPS8 (COPS8 Products)
    Synonyms
    COP9 antibody, CSN8 antibody, SGN8 antibody, csn8 antibody, cops8 antibody, MGC76051 antibody, MGC80215 antibody, DDBDRAFT_0167123 antibody, DDBDRAFT_0233107 antibody, DDB_0167123 antibody, DDB_0233107 antibody, zgc:56319 antibody, zgc:86840 antibody, MGC86182 antibody, 9430009J09Rik antibody, AA408242 antibody, Csn8 antibody, Sgn8 antibody, CONSTITUTIVE PHOTOMORPHOGENIC 9 antibody, COP9 SIGNALOSOME SUBUNIT 8 antibody, DL3095C antibody, EMB143 antibody, EMBRYO DEFECTIVE 143 antibody, FCAALL.131 antibody, FUS7 antibody, FUSCA 7 antibody, FUSCA PROTEIN FUS7 antibody, CG13383 antibody, CG33297 antibody, CG42522 antibody, CH8 antibody, Dch8 antibody, Dmel\\CG42522 antibody, Dmel_CG13383 antibody, l(2)SH1829 antibody, l(2)SH2 1829 antibody, COP9 signalosome subunit 8 antibody, COP9 signalosome subunit 8 S homeolog antibody, COP9 signalosome complex subunit 8 antibody, COP9 signalosome subunit 8 L homeolog antibody, COP9 signalosome, subunit CSN8 antibody, COPS8 antibody, Cops8 antibody, cops8 antibody, cops8.S antibody, CSN8 antibody, csn8 antibody, cops8.L antibody, COP9 antibody
    Background
    The COP9 signalosome (CSN) is an evolutionarily conserved protein complex of the eight subunits that interacts with deubiquitinating enzymes and protein kinases and is highly homologous to the lid sub-complex of 26S proteasome. The CSN complex is an essential regulator of the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-comlpexes such as SCF, CSA or DDB2. It is also involved in phosphorylation of p53, c-jun/JUN, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN8 encodes the smallest and the least conserved but first identified subunit of CSN. Recent studies show CSN8 is essential for Drosophila development and is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.Synonyms: COP9 signalosome complex subunit 8, CSN8, JAB1-containing signalosome subunit 8, SGN8, Signalosome subunit 8
    Gene ID
    10920
    NCBI Accession
    NP_006701
    UniProt
    Q99627
    Pathways
    Cell Division Cycle
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