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Chemokine (C-X-C Motif) Receptor 4 (CXCR4) (Isoform A), (N-Term) antibody

Details for Product No. ABIN499700
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Antigen
Synonyms
CXC-R4, CXCR-4, cd184, d2s201e, fb22, hm89, hsy3rr, lap3, lcr1, lestr, npy3r, npyr, npyrl, npyy3r, whim, xcxcr4, cxcr4, CD184, Cmkar4, LESTR, PB-CKR, PBSF/SDF-1, Sdf1r, D2S201E, FB22, HM89, HSY3RR, LA ... show more
CXC-R4, CXCR-4, cd184, d2s201e, fb22, hm89, hsy3rr, lap3, lcr1, lestr, npy3r, npyr, npyrl, npyy3r, whim, xcxcr4, cxcr4, CD184, Cmkar4, LESTR, PB-CKR, PBSF/SDF-1, Sdf1r, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, CXC-R4-B, CXCR-4-B, CXCR4, cb403, zgc:109863 show less
Epitope
Isoform A, N-Term
(53), (17), (13), (10), (8), (7), (7), (6), (6), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(216), (110), (64), (29), (13), (12), (3), (2), (1), (1), (1), (1)
Host
Rabbit
(177), (40), (20), (13), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(160), (78), (73), (60), (35), (28), (28), (27), (24), (8), (7), (6), (4), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN499700
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Immunogen A peptide corresponding to nine amino acids near the amino terminus of Human CXCR4 isoform a. (AP30268CP-N)
Isotype IgG
Specificity This antibody is specific for the longer isoform of CXCR4.
Purification Purified
Alternative Name CD184 / CXCR4
Background Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CXCR4 is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2. The a-chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV binding sites. This antibody is specific for the longer isoform of CXCR4.
Alternate names: C-X-C chemokine receptor type 4, CXC-R4, CXCR-4, FB22, Fusin, HM89, LCR1, LESTR, Leukocyte-derived seven transmembrane domain receptor, NPYRL, SDF1 receptor, Stromal cell-derived factor 1 receptor
Gene ID 7852
NCBI Accession NP_001008540
UniProt P61073
Research Area CD Antigens, Surface Receptors of Immune Cells, Chemokines, Receptors
Application Notes ELISA. Western Blot: 5 – 1 μg/ml. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Feng, Broder, Kennedy et al.: "HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor." in: Science (New York, N.Y.), Vol. 272, Issue 5263, pp. 872-7, 1996 (PubMed).

Doranz, Rucker, Yi et al.: "A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors." in: Cell, Vol. 85, Issue 7, pp. 1149-58, 1996 (PubMed).

Berson, Long, Doranz et al.: "A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains." in: Journal of virology, Vol. 70, Issue 9, pp. 6288-95, 1996 (PubMed).

Dimitrov: "How do viruses enter cells? The HIV coreceptors teach us a lesson of complexity." in: Cell, Vol. 91, Issue 6, pp. 721-30, 1998 (PubMed).

Validation Images
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