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TNFRSF10D antibody (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain) (AA 249-263)

Details for Product anti-TNFRSF10D Antibody No. ABIN499724, Supplier: Log in to see
Antigen
  • TNFRSF10D
  • CD264
  • DCR2
  • TRAIL-R4
  • TRAILR4
  • TRUNDD
Alternatives
anti-Human TNFRSF10D antibody for Immunofluorescence
Epitope
AA 249-263, Intracellular
15
14
13
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12
10
7
7
5
3
2
2
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
136
5
2
2
Host
Rabbit
103
32
1
Clonality
Polyclonal
Conjugate
This TNFRSF10D antibody is un-conjugated
8
7
6
6
6
4
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
84
62
38
30
6
5
3
2
2
1
1
1
1
Supplier
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Immunogen Human DcR2 (Intracellular Domain) Peptide corresponding to amino acids 249 to 263 of Human DcR2 precursor.
Isotype IgG
Specificity DcR2 antibody was raised against a peptide corresponding to amino acids 249 to 263 of Human DcR2 precursor.
Purification Affinity Chromatography purified via peptide column
Alternative Name CD264 / TRAILR4 (TNFRSF10D Antibody Abstract)
Background Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor (1-3). Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD (4-6). DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis.Synonyms: DCR2, Decoy receptor 2, TNF-related apoptosis-inducing ligand receptor 4, TNFRSF10D, TRAIL receptor 4, TRAIL receptor with a truncated death domain, TRAIL-R4, TRUNDD, Tumor necrosis factor receptor superfamily member 10D
Gene ID 8793
UniProt Q9UBN6
Research Area Signaling, Apoptosis/Necrosis
Pathways Apoptosis
Application Notes ELISA. Western Blot: 1/1000 to 1/2000. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Immunofluorescence (IF) image for anti-TNFRSF10D antibody (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain) (AA 249-263) (ABIN499724) Immunocytochemistry staining of HeLa cells using AP30280PU-N DcR2 antibody at 10μg/ml.
Western Blotting (WB) image for anti-TNFRSF10D antibody (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain) (AA 249-263) (ABIN499724) Western blot analysis of DcR2 in HeLa whole cell lysate with AP30280PU-N DcR2 antibod...
Background publications Pan, Ni, Yu et al.: "TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling." in: FEBS letters, Vol. 424, Issue 1-2, pp. 41-5, 1998 (PubMed).

Degli-Esposti, Dougall, Smolak et al.: "The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain." in: Immunity, Vol. 7, Issue 6, pp. 813-20, 1998 (PubMed).

Marsters, Sheridan, Pitti et al.: "A novel receptor for Apo2L/TRAIL contains a truncated death domain." in: Current biology : CB, Vol. 7, Issue 12, pp. 1003-6, 1998 (PubMed).

Sheridan, Marsters, Pitti et al.: "Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors." in: Science (New York, N.Y.), Vol. 277, Issue 5327, pp. 818-21, 1997 (PubMed).

Pan, Ni, Wei et al.: "An antagonist decoy receptor and a death domain-containing receptor for TRAIL." in: Science (New York, N.Y.), Vol. 277, Issue 5327, pp. 815-8, 1997 (PubMed).

Pan, ORourke, Chinnaiyan et al.: "The receptor for the cytotoxic ligand TRAIL." in: Science (New York, N.Y.), Vol. 276, Issue 5309, pp. 111-3, 1997 (PubMed).

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