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serine/threonine Kinase 17a (STK17A) (N-Term) antibody

Details for Product No. ABIN499768, Supplier: Log in to see
Antigen
  • STK17A
  • DRAK1
  • RDRAK1
  • serine/threonine kinase 17a
  • STK17A
  • stk17a
Epitope
N-Term
24
10
10
6
5
4
3
3
2
2
2
2
2
2
1
1
Reactivity
Human
103
32
19
7
5
5
5
4
3
2
2
Host
Rabbit
82
19
2
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
83
39
14
13
13
9
6
4
3
3
2
1
1
1
Options
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Immunogen Human DRAK1 (N-Terminus) Peptide
Isotype IgG
Specificity DRAK1 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human DRAK1. DRAK1 antibody has no cross responses to DRAK2, DAP or ZIP kinases.
Purification Affinity chromatography purified via peptide column
Alternative Name STK17A / DRAK1 (STK17A Antibody Abstract)
Background Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 for DAP kinase-related apoptosis-inducing protein kinases (1). DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK1 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK1 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues (1).Synonyms: DAP kinase-related apoptosis-inducing protein kinase 1, Serine/threonine-protein kinase 17A
Gene ID 9263
UniProt Q9UEE5
Application Notes ELISA. Western Blot: 0.5 - 1 μg/mL. A431 or MOLT4 whole cell lysate can be used as positivecontrol and an approximately 50 kDa band can be detected. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Immunofluorescence (IF) image for anti-serine/threonine Kinase 17a (STK17A) (N-Term) antibody (ABIN499768) Immunocytochemistry staining of MOLT4 cells using AP30302PU-N DRAK1 antibody at 2 μg/ml.
Western Blotting (WB) image for anti-serine/threonine Kinase 17a (STK17A) (N-Term) antibody (ABIN499768) Western blot analysis of DRAK1 in (A) MOLT4 and (B) A431 whole cell lysates with AP30...
Background publications Sanjo, Kawai, Akira: "DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis." in: The Journal of biological chemistry, Vol. 273, Issue 44, pp. 29066-71, 1998 (PubMed).