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Transmembrane Channel-Like 6 (TMC6) (Center) antibody

Details for Product No. ABIN499808, Supplier: Log in to see
Antigen
  • EVER1
  • zgc:92610
  • MGC83549
  • ever1
  • EV1
  • EVIN1
  • LAK-4P
  • D11Ertd204e
Epitope
Center
27
15
2
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
41
13
7
Host
Rabbit
43
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
40
29
17
5
2
1
Supplier
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Immunogen EVER1 antibody was raised against a 15 amino acid peptide from near the center of human EVER1.
Isotype IgG
Specificity This antibody reacts to EVER1.
Purification Affinity chromatography purified via peptide column
Alternative Name TMC6 / EVER1 (TMC6 Antibody Abstract)
Background Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes, EVER1 and EVER2, located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. Both EVER1 and EVER2 are members of the transmembrane channel-like (TMC) protein family. EVER1 possesses eight trans-membrane domains and two leucine zipper motifs. EVER1 and EVER2 form a complex and interact with the zinc transporter 1 (ZnT-1), suggesting that EVER1 and EVER2 act to regulate cellular zinc balance. At least four isoforms of EVER1 are known to exist. This EVER1 antibody does not cross-react with EVER2.Synonyms: EVIN1, Epidermodysplasia verruciformis protein 1, LAK-4, Transmembrane channel-like protein 6
Gene ID 11322
UniProt Q7Z403
Application Notes ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Transmembrane Channel-Like 6 (TMC6) (Center) antibody (ABIN499808) Immunohistochemistry of EVER1 in human spleen with EVER1 antibody at 2.5 μg/ml.
Western Blotting (WB) image for anti-Transmembrane Channel-Like 6 (TMC6) (Center) antibody (ABIN499808) Western blot analysis of EVER1 in human spleen tissue lysate with AP30322PU-N EVER1 a...
Background publications Lazarczyk, Pons, Mendoza et al.: "Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses." in: The Journal of experimental medicine, Vol. 205, Issue 1, pp. 35-42, 2008 (PubMed).

Keresztes, Mutai, Heller: "TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins." in: BMC genomics, Vol. 4, Issue 1, pp. 24, 2003 (PubMed).

Ramoz, Rueda, Bouadjar et al.: "Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis." in: Nature genetics, Vol. 32, Issue 4, pp. 579-81, 2002 (PubMed).

Majewski, Jab?o?ska, Orth: "Epidermodysplasia verruciformis. Immunological and nonimmunological surveillance mechanisms: role in tumor progression." in: Clinics in dermatology, Vol. 15, Issue 3, pp. 321-34, 1997 (PubMed).