FAIM antibody (C-Term)
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- Target See all FAIM Antibodies
- FAIM (Fas Apoptotic Inhibitory Molecule (FAIM))
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Binding Specificity
- C-Term
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This FAIM antibody is un-conjugated
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Specificity
- This antibody reacts to FAIM.
- Purification
- Affinity chromatography purified via peptide column
- Immunogen
- FAIM antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human FAIM.
- Isotype
- IgG
- Top Product
- Discover our top product FAIM Primary Antibody
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- Application Notes
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ELISA. Western Blot: 5 - 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Buffer
- PBS containing 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store the antibody undiluted at 2-8 °C.
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- Target
- FAIM (Fas Apoptotic Inhibitory Molecule (FAIM))
- Alternative Name
- FAIM (FAIM Products)
- Synonyms
- FAIM1 antibody, FAIM antibody, faim antibody, zgc:92712 antibody, zgc:92723 antibody, Fas apoptotic inhibitory molecule antibody, Fas apoptotic inhibitory molecule L homeolog antibody, Fas apoptotic inhibitory molecule b antibody, Fas apoptotic inhibitory molecule a antibody, FAIM antibody, Faim antibody, faim antibody, faim.L antibody, Tsp_00038 antibody, faimb antibody, faima antibody
- Background
- The susceptibility of primary splenic B cells to Fas-mediated apoptosis is regulated in a receptor-specific fashion. Terminal effectors of B cell Fas-resistance include the known anti-apoptotic proteins Bcl-xL, FLIP, and a recently identified protein termed FAIM. This molecule is broadly expressed in various tissues and exists in at least three isoforms. It is thought that resistance to Fas killing via increased expression of FAIM protects foreign antigen-specific B cells during interactions with FasL-bearing T cells whereas autoreactive B cells are deleted via Fas-dependent cytotoxicity. More recent results have indicated that FAIM interacts with both Trk and p75 neurotrophin receptor and may play a role in promoting neurite outgrowth in different neuronal systems by a mechanism involving the activation of NF-kappaB and the Ras-ERK pathway.Synonyms: FAIM-1, FAIM1, Fas Apoptotic Inhibitory Molecule 1
- Gene ID
- 55179
- NCBI Accession
- NP_060617
- UniProt
- Q9NVQ4
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