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GPR3 antibody (C-Term)

GPR3 Reactivity: Human, Mouse, Rat WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499914
  • Target See all GPR3 Antibodies
    GPR3 (G Protein-Coupled Receptor 3 (GPR3))
    Binding Specificity
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 30
    • 16
    • 14
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 28
    • 4
    • 1
    Rabbit
    Clonality
    • 31
    • 2
    Polyclonal
    Conjugate
    • 21
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GPR3 antibody is un-conjugated
    Application
    • 16
    • 13
    • 10
    • 7
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts to GPR3.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    GPR3 antibody was raised against a 13 amino acid peptide from near the carboxy terminus of human GPR3.
    Isotype
    IgG
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    Discover our top product GPR3 Primary Antibody
  • Application Notes
    ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    GPR3 (G Protein-Coupled Receptor 3 (GPR3))
    Alternative Name
    GPR3 / ACCA (GPR3 Products)
    Synonyms
    GPR3 antibody, ACCA antibody, Gpcr3 antibody, Gpcr20 antibody, Gpcr21 antibody, G protein-coupled receptor 3 antibody, G-protein coupled receptor 3 antibody, GPR3 antibody, Gpr3 antibody
    Background
    GPR3, also known as ACCA, is a G-protein coupled receptor that constitutively activates adenylate cyclase and is highly expressed in the central nervous system. Overexpression of GPR3 stimulates the production of amyloid-b peptide (Ab), the deposition of which is one of the pathological hallmarks of Alzheimer 's disease (AD), while the ablation of GPR3 prevented the accumulation of Ab in vitro and in an AD mouse model. This is of particular interest because of the proximity of a reported candidate Alzheimer 's disease (AD) locus, suggesting that GPR3 may be a potential therapeutic target for the treatment of AD. GPR3 has also been shown to block the proliferation of cerebellar granule cell precursors (GCP) during postnatal development by inhibiting the Shh-induced proliferation of GCP, indicating that GPR3 activation may represent one of the signals that triggers the postnatal cell cycle exit and terminal differentiation of GPCs.Synonyms: ACCA orphan receptor, G-protein coupled receptor 3
    Gene ID
    2827
    UniProt
    P46089
    Pathways
    cAMP Metabolic Process
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