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Details for Product No. ABIN500036

Interleukin-1 Receptor-Associated Kinase 1 (IRAK1) (C-Term) antibody

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Antigen
Synonyms IRAK, pelle, Plpk, mPLK, IRAK-1, Il1rak, IRAK1-S, AA408924, RGD1563841, IRAK1
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN500036
Quantity 0.1 mg
Price
390.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Human IRAK (C-Terminus) Peptide (AP30438CP-N)
Isotype IgG
Specificity IRAK antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human IRAK.
Purification DEAE
Alternative Name IRAK1
Background Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF- kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-kappaB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).
Alternate names: IRAK, IRAK-1, Interleukin-1 receptor-associated kinase 1
Gene ID 3654
NCBI Accession P51617
UniProt P51617
Research Area Cytokines, Receptors, Inflammation
Application Notes ELISA. Western Blot: 1/1000. Immunocytochemistry. Immunoprecipitation: 2 to 4 µg per sample. An 80 kDa band should be detected in the lysate from non-activated cells. It has no crossresponse to IRAK2. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Cao, Henzel, Gao: "IRAK: a kinase associated with the interleukin-1 receptor." in: Science (New York, N.Y.), Vol. 271, Issue 5252, pp. 1128-31, 1996 (PubMed).

Trofimova, Sprenkle, Green et al.: "Developmental and tissue-specific expression of mouse pelle-like protein kinase." in: The Journal of biological chemistry, Vol. 271, Issue 30, pp. 17609-12, 1996 (PubMed).

Robinson, Shibuya, Mui et al.: "IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB." in: Immunity, Vol. 7, Issue 4, pp. 571-81, 1997 (PubMed).

Huang, Gao, Li et al.: "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 24, pp. 12829-32, 1998 (PubMed).

Yao, Li, Shi: "Optically active supramolecular complexes of water-soluble achiral polythiophenes and folic acid: spectroscopic studies and sensing applications." in: Langmuir : the ACS journal of surfaces and colloids, Vol. 24, Issue 22, pp. 12829-35, 2008 (PubMed).

Alternatives for antigen "Interleukin-1 Receptor-Associated Kinase 1 (IRAK1)", type "Antibodies"
Hosts (151), (31), (1)
Reactivities (156), (89), (73), (36), (24), (24), (12)
Applications (121), (91), (50), (44), (32), (30), (20), (13), (6), (3), (3), (1)
Conjugates (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Epitopes (29), (26), (21), (16), (8), (8), (6), (5), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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