Lysine (K)-Specific Demethylase 3B (KDM3B) (Center) antibody

Details for Product No. ABIN500076
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Antigen
Synonyms KDM3B, JMJD1B, 5830462I21Rik, JHDM2B, Jmjd1b, mKIAA1082, 5qNCA, C5orf7, NET22
Epitope
Center
(11), (7), (7), (5), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(63), (26), (23), (14), (14), (12), (2), (2), (2)
Host
Rabbit
(60), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(43), (26), (10), (9), (8), (7), (5), (4), (4), (4), (2), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN500076
401.50 $
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Immunogen JMJD1B antibody was raised against a 20 amino acid peptide from near the center of human JMJD1B.
Isotype IgG
Specificity This antibody detects JMJD1B. It will not cross-react with JMJD1A or JMJD1C.
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse, rat
Purification Peptide affinity chromatography
Alternative Name JMJD1B / KDM3B
Background The jumonji domain containing 1B protein (JMJD1B) was originally discovered as a candidate for the myeloid leukemia tumor suppressor gene. Besides CD34+ cells and acute myeloid leukemia (AML) cell lines, JMJD1B mRNA is highly expressed in liver, heart, kidney, skeletal muscle, and placenta tissues. The JMJD1B gene is localized to a region of chromosome 5q31, which is frequently deleted in myeloid leukemias and myelodysplasias and expression of JMJD1B in a del(5q) cell line results in suppression of clonogenic growth suggesting that JMJD1B may function as a tumor suppressor. In contrast, JMJD1B gene copy number and mRNA expression level was increased in several non-small cell lung cancers indicating that the role of JMJD1B in cancer formation and progression is more complex than originally postulated. At least three isoforms of JMJD1B are known to exist.Synonyms: 5qNCA, C5orf7, JHDM2B, JmjC domain-containing histone demethylation protein 2B, Jumonji domain-containing protein 1B, KIAA1082, Lysine-specific demethylase 3B, Nuclear protein 5qNCA
Gene ID 51780
NCBI Accession NP_057688
UniProt Q7LBC6
Application Notes ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Background publications Lai, Godley, Fernald et al.: "cDNA cloning and genomic structure of three genes localized to human chromosome band 5q31 encoding potential nuclear proteins." in: Genomics, Vol. 70, Issue 1, pp. 123-30, 2001 (PubMed).

Hu, Gomes, Horrigan et al.: "A novel nuclear protein, 5qNCA (LOC51780) is a candidate for the myeloid leukemia tumor suppressor gene on chromosome 5 band q31." in: Oncogene, Vol. 20, Issue 47, pp. 6946-54, 2001 (PubMed).

Jarczowski, Fischer, Edlich: "FKBP36 forms complexes with clathrin and Hsp72 in spermatocytes." in: Biochemistry, Vol. 47, Issue 26, pp. 6946-52, 2008 (PubMed).

Baik, Jee, Choi et al.: "DNA profiling by array comparative genomic hybridization (CGH) of peripheral blood mononuclear cells (PBMC) and tumor tissue cell in non-small cell lung cancer (NSCLC)." in: Molecular biology reports, Vol. 36, Issue 7, pp. 1767-78, 2009 (PubMed).

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