LGI4 antibody (Center)

Catalog No. ABIN500162

Product Details anti-LGI4 Antibody

Target: LGI4 (Leucine-Rich Repeat LGI Family, Member 4 (LGI4))

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LGI4 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects LGI4 at center (only the larger form). It is predicted to be specific to LGI4 and not recognize other LGI proteins.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogen: LGI4 antibody was raised against a 14 amino acid peptide from near the center of human LGI4.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for LGI4

Target: LGI4 (Leucine-Rich Repeat LGI Family, Member 4 (LGI4))

Alternative Name: LGI4 (LGI4 Products)

Synonyms: Lgil3 antibody, clp antibody, LGIL3 antibody, leucine rich repeat LGI family member 4 antibody, leucine-rich repeat LGI family, member 4 antibody, LGI4 antibody, Lgi4 antibody

Background: The leucine-rich, glioma inactivated gene 4 (LGI4) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI4 have not been found to be associated with ADTLE. However, the LGI4 gene is located in a region linked to benign familial infantile convulsions. Further study revealed that a GC-to-AT polymorphism was correlated with childhood absence epilepsy. Other studies showed that decreasing LGI4 expression in cultured cells inhibits myelination, indicating that LGI4 may play a role in neural development. Two isoforms of LGI4 are known to exist.Synonyms: LGI1-like protein 3, LGI4, LGIL3, Leucine-rich glioma-inactivated protein 4, Leucine-rich repeat LGI family member 4

Gene ID: 163175

UniProt: Q8N135