Myeloid Differentiation Primary Response Gene (88) (MYD88) (AA 279-296), (C-Term) antibody

Details for Product No. ABIN500302
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Antigen
Synonyms XMyD88, myd88d, MGC84928, CG2078, DMMYD88, DmMyD88, DmMyd88, Dmel\\CG2078, EP(2)2535, Kra, LD20892, MYD88, MyD88, Myd88F, dMyD88, dMyd88, kra, myd88, zgc:103541, GB12344, NV10640, irak-2, MYD88D
Epitope
AA 279-296, C-Term
(16), (14), (12), (8), (8), (6), (5), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(139), (64), (40), (4), (3), (3), (2), (1), (1), (1), (1)
Host
Rabbit
(118), (31), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(136), (45), (43), (23), (16), (13), (10), (8), (8), (6), (5), (4), (3), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN500302
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Immunogen MyD88 antibody was raised against a peptide corresponding to amino acids 279 to 296 of human MyD88, which are identical to those of mouse.
Isotype IgG
Specificity This antibody detects MYD88 at C-term.
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse, rat
Purification Peptide affinity chromatography
Alternative Name MYD88
Background The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. Recently, MyD88 was identified as an adapter molecule in the IL-1 signaling pathway (1). MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-kappaB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor (2,3), which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.Synonyms: Myeloid differentiation primary response protein MyD88
Gene ID 4615
UniProt Q99836
Application Notes ELISA. Western blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Background publications Muzio, Ni, Feng et al.: "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling." in: Science (New York, N.Y.), Vol. 278, Issue 5343, pp. 1612-5, 1997 (PubMed).

Adachi, Kawai, Takeda et al.: "Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function." in: Immunity, Vol. 9, Issue 1, pp. 143-50, 1998 (PubMed).

Medzhitov, Preston-Hurlburt, Kopp et al.: "MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways." in: Molecular cell, Vol. 2, Issue 2, pp. 253-8, 1998 (PubMed).

Kawai, Adachi, Ogawa et al.: "Unresponsiveness of MyD88-deficient mice to endotoxin." in: Immunity, Vol. 11, Issue 1, pp. 115-22, 1999 (PubMed).

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