Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) (Middle Region) antibody
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- Target See all Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) Antibodies
- Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1)
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Binding Specificity
- Middle Region
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- Un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- Specificity
- This antibody detects NADE / BEX3.
- Cross-Reactivity (Details)
- Species reactivity (tested):Human, mouse
- Purification
- Ion exchange chromatography
- Immunogen
- NADE antibody was raised against a peptide corresponding to 14 amino acids near the middle of human NADE.
- Isotype
- IgG
- Top Product
- Discover our top product NGFRAP1 Primary Antibody
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- Application Notes
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ELISA. Western blot: 0.5 to 2 μg/mL. Despite its predicted molecular weight, NADE migrates at approx. 23 kDa in SDS-PAGE. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Buffer
- PBS containing 0.02 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- Target
- Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1)
- Alternative Name
- NADE / BEX3 (NGFRAP1 Products)
- Synonyms
- BEX3 antibody, Bex antibody, DXS6984E antibody, HGR74 antibody, NADE antibody, NGFRAP1 antibody, LNGFR antibody, Tnfrsf16 antibody, p75 antibody, p75NGFR antibody, p75NTR antibody, AL033356 antibody, Bex3 antibody, DXWsu67e antibody, Gcap27 antibody, Nade antibody, WBP5 antibody, brain expressed X-linked 3 antibody, nerve growth factor receptor (TNFR superfamily, member 16) antibody, BEX3 antibody, Ngfr antibody, Bex3 antibody
- Background
- The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF) (1 for review). The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR (2). Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac). Co-expression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization. It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed (5). Finally, although initially discovered as an mRNA expressed in ovarian granulosa cells (3), NADE has been suggested to play a role in the neuronal death seen in epileptic brain damage (4).Synonyms: Brain-expressed X-linked protein 3, DXS6984E, NGFRAP1, p75NTR-associated cell death executor
- Gene ID
- 27018
- NCBI Accession
- NP_996798
- UniProt
- Q00994
- Pathways
- Neurotrophin Signaling Pathway, Positive Regulation of Endopeptidase Activity
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