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RCAN2 antibody (Center)

RCAN2 Reactivity: Human, Mouse, Rat WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500577
  • Target See all RCAN2 Antibodies
    RCAN2 (Regulator of Calcineurin 2 (RCAN2))
    Binding Specificity
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reactivity
    • 28
    • 19
    • 12
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Human, Mouse, Rat
    Host
    • 26
    • 2
    Rabbit
    Clonality
    • 28
    Polyclonal
    Conjugate
    • 12
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RCAN2 antibody is un-conjugated
    Application
    • 16
    • 13
    • 8
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects Calcipressin-2.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogen
    RCAN2 antibody was raised against a 14 amino acid peptide near the center of human RCAN2.
    Isotype
    IgG
    Top Product
    Discover our top product RCAN2 Primary Antibody
  • Application Notes
    ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    RCAN2 (Regulator of Calcineurin 2 (RCAN2))
    Alternative Name
    Calcipressin-2 (RCAN2 Products)
    Synonyms
    DSCR1L1 antibody, si:ch211-124g24.1 antibody, zgc:85746 antibody, RCAN2 antibody, DKFZp459H071 antibody, rcan2 antibody, CSP2 antibody, MCIP2 antibody, RCN2 antibody, ZAKI-4 antibody, ZAKI4 antibody, Csp2 antibody, Dscr1l1 antibody, Dcip2 antibody, Zaki-4 antibody, regulator of calcineurin 2 antibody, rcan2 antibody, RCAN2 antibody, Rcan2 antibody
    Background
    Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin's activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.Synonyms: DSCR1L1, Down syndrome candidate region 1-like 1, Myocyte-enriched calcineurin-interacting protein 2, RCAN2, Regulator of calcineurin 2, Thyroid hormone-responsive protein ZAKI-4, ZAKI4
    Gene ID
    53901
    UniProt
    Q9JHG2
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