Ubiquitin-Conjugating Enzyme E2 Variant 1 (UBE2V1) (C-Term) antibody

Details for Product No. ABIN501100
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Antigen
Synonyms CIR1, UEV1, CROC1, UBE2V, UEV-1, UEV1A, CROC-1, 0610011J09Rik, AI256840, D7Bwg1382e, CROC-1B, TMEM189-UBE2V1, UBE2V1, UBE2V2
Epitope
C-Term
(18), (3), (3), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(58), (25), (23), (11), (11)
Host
Rabbit
(51), (5), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(48), (27), (9), (8), (4), (2), (1)
Pubmed 4 references available
Catalog no. ABIN501100
Quantity 0.1 mg
Price
357.50 $   Plus shipping costs $45.00
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  • +1 404 474 4654
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Immunogen UEV1A antibody was raised against a peptide corresponding to 15 amino acids near the C- terminus of human UEV1A.
Isotype IgG
Specificity This antibody detects UBE2V1 / CROC1.
Purification Ion exchange chromatography
Alternative Name UBE2V1 / CROC1
Background Ubiquitin-conjugating enzyme E2 (UEV1) was initially discovered as a protein similar in sequence and structure to the E2 ubiquitin-conjugating enzymes but lacking their enzymatic activity (1). There are at least two variants and multiple isoforms of UEV1. In particular, UEV1A (Ubiquitin-conjugating enzyme E2 variant 1 isoform A) has recently been shown to be an important component of the Toll-like receptor and IL-1R signaling pathway (reviewed in 2). Signals from these pathways are relayed by a number of downstream molecules such as MyD88 and tumor necrosis factor receptor associated factor (TRAF6), ultimately activating various kinases and transcription factors (2,3). UEV1A is part of a dimeric ubiquitin-conjugating enzyme complex also containing Ubc13 (ubiquitin- conjugating enzyme 13) that together with TRAF6 activates TAK1, a member of the mitogen- activated protein kinase kinase kinase family (4-6). The Ubc13-UEV1A complex also mediates the Lys-63 ubiquitination of TRAF-6, and this ubiquitination is essential for TAK1 activation (5).
Alternate names: CROC-1, P/OKcl.19, TRAF6-regulated IKK activator 1 beta Uev1A, UBE2V, UEV-1, UEV1, Ubiquitin-conjugating enzyme E2 variant 1
Gene ID 387522
NCBI Accession NP_954595
Application Notes ELISA. Western blot: 1 to 2 μg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Sancho, Vilá, Sánchez-Pulido et al.: "Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells." in: Molecular and cellular biology, Vol. 18, Issue 1, pp. 576-89, 1998 (PubMed).

Deng, Wang, Spencer et al.: "Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain." in: Cell, Vol. 103, Issue 2, pp. 351-61, 2000 (PubMed).

Vogel, Fitzgerald, Fenton: "TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression." in: Molecular interventions, Vol. 3, Issue 8, pp. 466-77, 2004 (PubMed).

Akira, Takeda: "Toll-like receptor signalling." in: Nature reviews. Immunology, Vol. 4, Issue 7, pp. 499-511, 2004 (PubMed).

Hosts (51), (5), (4)
Reactivities (58), (25), (23), (11), (11)
Applications (48), (27), (9), (8), (4), (2), (1)
Conjugates (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (18), (3), (3), (2), (2), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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