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MAVS antibody (Mitochondrial Antiviral Signaling Protein) (Middle Region)

Details for Product anti-MAVS Antibody No. ABIN501120, Supplier: Log in to see
Antigen
  • cardif
  • CARDIF
  • D430028G21Rik
  • HISPPD2A
  • hsVIP1
  • IP6K
  • IPS-1
  • IPS1
  • VIP1
  • Visa
  • VISA
Epitope
Middle Region
34
23
18
15
7
5
3
3
3
2
2
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
164
55
33
1
Host
Rabbit
117
67
Clonality
Polyclonal
Conjugate
This MAVS antibody is un-conjugated
8
8
7
5
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
163
52
49
40
12
11
8
8
2
2
1
Supplier
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Immunogen VISA antibody was raised against a 17 amino acid peptide from near the center of human VISA.
Isotype IgG
Specificity This antibody detects MAVS at Center.
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse, rat
Purification Affinity chromatography
Alternative Name MAVS (MAVS Antibody Abstract)
Background Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappaB. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKKalpha, IKKbeta and IKKepsilon kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.Synonyms: CARD adapter inducing interferon-beta, Cardif, IPS1, Mitochondrial antiviral-signaling protein, Mitochondrial antiviral-signaling protein, Putative NF-kappa-B-activating protein 031N, VISA, Virus-induced-signaling adapter, nterferon-beta promoter stimulator protein 1
Gene ID 57506
NCBI Accession NP_065797
Research Area Immunology
Application Notes ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-MAVS antibody (Mitochondrial Antiviral Signaling Protein) (Middle Region) (ABIN501120) Immunohistochemistry of VISA in mouse brain tissue with this product at 2.5 μg/ml.
Western Blotting (WB) image for anti-MAVS antibody (Mitochondrial Antiviral Signaling Protein) (Middle Region) (ABIN501120) Western blot analysis of VISA in rat brain tissue lysate with this product at (A) 0.5...
Background publications Seth, Sun, Chen: "Antiviral innate immunity pathways." in: Cell research, Vol. 16, Issue 2, pp. 141-7, 2006

Xu, Wang, Han, Li, Zhai, Shu: "VISA is an adapter protein required for virus-triggered IFN-beta signaling." in: Molecular cell, Vol. 19, Issue 6, pp. 727-40, 2005

Meylan, Curran, Hofmann, Moradpour, Binder, Bartenschlager, Tschopp: "Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus." in: Nature, Vol. 437, Issue 7062, pp. 1167-72, 2005