KCNJ4 antibody (Middle Region)

Catalog No. ABIN501375

The Rabbit Polyclonal anti-KCNJ4 antibody (ABIN501375) specifically detects KCNJ4 in WB. The antibody is reactive with Human, Mouse, Rat, Dog, Guinea Pig and Rabbit samples.

Quick Overview for KCNJ4 antibody (Middle Region) (ABIN501375)

Target: KCNJ4 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 4 (KCNJ4))

Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNJ4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KCNJ4 Antibody

Binding Specificity: Middle Region

Sequence: AVAAGLGLEA GSKEEAGIIR MLEFGSHLDL ERMQASLPLD NISYRRESAI

Predicted Reactivity: Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against KCNJ4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human KCNJ4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 445 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KCNJ4

Target: KCNJ4 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 4 (KCNJ4))

Alternative Name: KCNJ4

Background: KCNJ4 is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have??een found for this gene. Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neuronsSeveral different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene.
Alias Symbols: HIR, HIRK2, HRK1, IRK3, Kir2.3, MGC142066, MGC142068, IRK-3
Protein Interaction Partner: SNTA1, LIN7B, GNGT2, DLG2, IL16, DLG4, DLG1, KCNJ2, CASK, PRKCD, LIN7C, LIN7A, DMD,
Protein Size: 445

Molecular Weight: 49 kDa

Gene ID: 3761

NCBI Accession: NM_004981, NP_004972

UniProt: P48050