Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 6 (KCNH6) (Middle Region) antibody

Details for Product No. ABIN501419
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Antigen
Synonyms KCNH2, erg, ERG-2, ERG2, HERG2, Kv11.2, hERG-2, m-erg2, Erg2
Epitope
Middle Region
(3), (2), (2), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine), Human
(13), (4), (3), (3), (2), (1), (1)
Host
Rabbit
(12), (1)
Clonality
Polyclonal
Application
Western Blotting (WB)
(12), (4), (1), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN501419
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Immunogen Synthetic peptide directed towards the middle region of human KCNH6
Sequence PLASPLHPLE VQGLICGPCF SSLPEHLGSV PKQLDFQRHG SDPGFAGSWG
Predicted Reactivity Human : 100 %, Bovine : 90 %, Horse : 90 %, Mouse : 90 %, Rabbit : 90 %, Rat : 90 %, Pig : 80 %, Dog : 80 %
Characteristics This is a rabbit polyclonal antibody against KCNH6. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name KCNH6
Background Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. KCNH6 encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.
Molecular Weight 100 kDa
Gene ID 81033
NCBI Accession NM_173092, NP_775115
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 905 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 6 (KCNH6) (Middle Region) antibody WB Suggested Anti-KCNH6 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: NCI-H226 cell lysate
Background publications Gutman, Chandy, Grissmer et al.: "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels." in: Pharmacological reviews, Vol. 57, Issue 4, pp. 473-508, 2005 (PubMed).

Validation Images
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