Suppressor of Fused Homolog (Drosophila) (SUFUH) (Middle Region) antibody

Details for Product No. ABIN501788
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Antigen
Synonyms CG6054, Dmel\\CG6054, SU(FU), SUFU, Su(Fu), SuFu, Sufu, su(fu), sufu, Xsufu, sufuh, sufuxl, PRO1280, SUFUH, SUFUXL, Su(fu), dre, fi39e05, wu:fi39e05, 2810026F04Rik, b2b273Clo
Epitope
Middle Region
(8), (5), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Xenopus laevis, Dog (Canine), Zebrafish (Danio rerio), Human, Chicken
(41), (20), (19), (15), (14), (13), (8), (3), (2), (2), (1)
Host
Rabbit
(44), (3), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(27), (10), (9), (8), (6), (3), (2), (2), (1), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN501788
289.00 $
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Immunogen Synthetic peptide directed towards the middle region of human SUFU
Sequence LQILLTEEFV EKMLEDLEDL TSPEEFKLPK EYSWPEKKLK VSILPDVVFD
Predicted Reactivity African clawed frog : 100 %, Chicken : 100 %, Dog : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %, Zebrafish : 90 %
Characteristics This is a rabbit polyclonal antibody against SUFU. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name SUFU
Background SUFU is a component of the Sonic hedgehog (SHH, MIM 600725)/Patched (PTCH, MIM 601309) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes.SUFU encodes a component of the sonic hedgehog (SHH, MIM 600725)/patched (PTCH, MIM 601309) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes (e.g., HPE3, MIM 142945, BCNS, MIM 109400, and GCPS, MIM 175700).
Molecular Weight 54 kDa
Gene ID 51684
NCBI Accession NM_016169, NP_057253
UniProt Q9UMX1
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 484 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Suppressor of Fused Homolog (Drosophila) (SUFUH) (Middle Region) antibody WB Suggested Anti-SUFU Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: HepG2 cell lysate
anti-Suppressor of Fused Homolog (Drosophila) (SUFUH) (Middle Region) antibody (2) Immunohistochemistry with Uterus tissue at an antibody concentration of 5µg/ml using anti-SUFU antibody (ARP39233_P050)
Background publications Lee, Deng, Wang et al.: "MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 51, pp. 20350-5, 2007 (PubMed).

Validation Images
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