Eukaryotic Translation Initiation Factor 2, Subunit 3 Gamma, 52kDa (EIF2S3) (N-Term) antibody

Details for Product No. ABIN502695
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Antigen
Synonyms EIF2S3, eif2, eif2g, eif2s3y, eif2gamma, Su(var)3-9, fi03g03, wu:fi03g03, wu:fi37d04, zgc:63805, EIF2, EIF2G, EIF2gamma, eIF-2gA, Eif2g, Eif2s3, PP42, ENSMUSG00000079297
Epitope
N-Term
(7), (6), (5), (2), (2), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine), Xenopus laevis, Human, Chicken
(24), (6), (6), (2), (2), (1), (1)
Host
Rabbit
(19), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(24), (14), (5), (3), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN502695
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human EIF2S3
Sequence AGGEAGVTLG QPHLSRQDLT TLDVTKLTPL SHEVISRQAT INIGTIGHVA
Predicted Reactivity Chicken : 100 %, Dog : 100 %, Human : 100 %, Mouse : 100 %, Rat : 100 %, African clawed frog : 90 %, Bovine : 90 %
Characteristics This is a rabbit polyclonal antibody against EIF2S3. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name EIF2S3
Background EIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
Molecular Weight 51 kDa
Gene ID 1968
NCBI Accession NM_001415, NP_001406
UniProt P41091
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 472 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Background publications Tu, Yan, Hood et al.: "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 4, pp. 575-88, 2007 (PubMed).

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