Cadherin 12 antibody (Middle Region)
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- Target See all Cadherin 12 Antibodies
- Cadherin 12
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Binding Specificity
- Middle Region
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Reactivity
- Human, Rat, Mouse, Dog, Guinea Pig, Rabbit, Cow, Horse, Zebrafish (Danio rerio)
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Cadherin 12 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- DTQEGVIKLK KPLDFETKKA YTFKVEASNL HLDHRFHSAG PFKDTATVKI
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
- Characteristics
- This is a rabbit polyclonal antibody against CDH12. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human CDH12
- Top Product
- Discover our top product Cadherin 12 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 794 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- Cadherin 12
- Alternative Name
- CDH12 (Cadherin 12 Products)
- Synonyms
- CDHB antibody, Cdhb antibody, RGD1566350 antibody, cdh12 antibody, cadherin 12 antibody, cadherin-12 antibody, CDH12 antibody, Cdh12 antibody, LOC570372 antibody
- Background
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CDH12 belongs to the protocadherin protein family, a subfamily of the cadherin superfamily. It consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The function of this cellular adhesion protein is undetermined but mouse protocadherin 12 does not bind catenins and appears to have no affect on cell migration or growth.This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.
Alias Symbols: CDHB, FLJ34857
Protein Interaction Partner: CDH7, CDH18,
Protein Size: 794 - Molecular Weight
- 82 kDa
- Gene ID
- 1010
- NCBI Accession
- NM_004061, NP_004052
- UniProt
- P55289
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