anti-MAP3K2 antibody (Mitogen-Activated Protein Kinase Kinase Kinase 2) (N-Term)

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Antigen
Synonyms Mekk2, MEKK2, MEKK2B, 9630061B06Rik, AI585793, Mekk2b
Alternatives
Epitope
N-Term
(19), (14), (7), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Dog (Canine), Human, Mouse (Murine)
(49), (12), (10)
Host
Rabbit
(44), (6)
Clonality
Polyclonal
Conjugate
This MAP3K2 antibody is un-conjugated
(2), (2), (2), (2), (2), (2), (1)
Application
Western Blotting (WB)
(46), (20), (19), (6), (5), (5), (4), (3), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the N terminal of human MAP3K2
Blocking Peptide Blocking peptide for this product available: Mitogen-Activated Protein Kinase Kinase Kinase 2 (MAP3K2) peptide (ABIN979777)
Sequence AERKKRLSII GPTSRDRSSP PPGYIPDELH QVARNGSFTS INSEGEFIPE
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Guinea pig : 90 %, Rabbit : 90 %, Mouse : 80 %, Rat : 80 %, Horse : 80 %, Chicken : 70 %
Characteristics This is a rabbit polyclonal antibody against MAP3K2. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name MAP3K2 (MAP3K2 Antibody Abstract)
Background MAP3K2 is a component of a protein kinase signal transduction cascade. It regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7. It also plays a role in caveolae kiss-and-run dynamics.The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process.
Molecular Weight 70 kDa
Gene ID 10746
NCBI Accession NP_006600, NM_006609
UniProt Q9Y2U5
Pathways MAPK Signaling
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 619 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-MAP3K2 antibody (Mitogen-Activated Protein Kinase Kinase Kinase 2) (N-Term) (ABIN503027) WB Suggested Anti-MAP3K2 Antibody Titration: 0.2-1 ug/ml
Positive Contro...
Western Blotting (WB) image for anti-MAP3K2 antibody (Mitogen-Activated Protein Kinase Kinase Kinase 2) (N-Term) (ABIN503027) WB Suggested Anti-MAP3K2
Antibody Titration: 0.2-1 µg/mL
Positive Contr...
Background publications Wissing, Jänsch, Nimtz et al.: "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 3, pp. 537-47, 2007 (PubMed).

Catalog No. ABIN503027
$289.00
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