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Details for Product No. ABIN503289

Centromere Protein B (CENPB) (C-Term) antibody

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Antigen
Synonyms CENPB
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine), Zebrafish (Danio rerio), Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN503289
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-CENPB antibody: synthetic peptide directed towards the C terminal of human CENPB
Sequence GGEDSDSDSEEEDDEEEDDEDEDDDDDEEDGDEVPVPSFG EAMAYFAMVK
Predicted Reactivity Human : 100%, Mouse : 92%, Rat : 92%, Dog : 85%, Horse : 85%, Pig : 85%, Sheep : 85%
Characteristics This is a rabbit polyclonal antibody against CENPB. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name CENPB
Background CENPB is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.
Molecular Weight 65kDa
Gene ID 1059
NCBI Accession NP_001801, NM_001810
UniProt P07199
Research Area Chromatin and Nuclear Signaling, Cell Cycle
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-CENPB antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Orthaus, Biskup, Hoffmann et al.: "Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human cells." in: Chembiochem : a European journal of chemical biology, Vol. 9, Issue 1, pp. 77-92, 2007 (PubMed).

Alternatives for antigen "Centromere Protein B (CENPB)", type "Antibodies"
Hosts (16), (1)
Reactivities (16), (12), (12), (12), (12)
Applications (10), (7), (4), (3), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (2), (2)
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