Actin-Like 7b (Actl7b) (Middle Region) antibody

Details for Product No. ABIN503490
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Antigen
Synonyms ACTL7B, Tact1
Epitope
Middle Region
(13), (8), (7), (7), (4), (2), (2), (1), (1)
Reactivity
Rat (Rattus), Mouse (Murine), Human
(28), (16), (5)
Host
Rabbit
(28), (10), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(39), (27), (4), (4), (2)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN503490
289.00 $
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Immunogen Synthetic peptide directed towards the middle region of human ACTL7B
Sequence KLITIGQERF RCSEMLFQPS LAGSTQPGLP ELTAACLGRC QDTGFKEEMA
Predicted Reactivity Crab-eating macaque :100 %,   Human :100 %,   Rat :90 %,   Mouse :80 %,  
Characteristics This is a rabbit polyclonal antibody against ACTL7B. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name ACTL7B
Background ACTL7B is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known.The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known.
Molecular Weight 46 kDa
Gene ID 10880
NCBI Accession NM_006686, NP_006677
UniProt Q9Y614
Research Area Signaling, Cytoskeleton, Microfilaments
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 416 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Actin-Like 7b (Actl7b) (Middle Region) antibody WB Suggested Anti-ACTL7B Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Transfected 293T
Background publications Humphray, Oliver, Hunt et al.: "DNA sequence and analysis of human chromosome 9." in: Nature, Vol. 429, Issue 6990, pp. 369-74, 2004 (PubMed).

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