ERCC6L antibody (N-Term)

Catalog No. ABIN504145

This Rabbit Polyclonal antibody specifically detects ERCC6L in WB. It exhibits reactivity toward Human, Rat, Horse, Cow, Dog, Pig and Rabbit.

Quick Overview for ERCC6L antibody (N-Term) (ABIN504145)

Target: ERCC6L (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6-Like (ERCC6L))

Reactivity: Human, Rat, Horse, Cow, Dog, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERCC6L antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ERCC6L Antibody

Binding Specificity: N-Term

Sequence: GDLEEAFKLF NLAKDIFPNE KVLSRIQKIQ EALEELAEQG DDEFTDVCNS

Predicted Reactivity: Cow: 93%, Dog: 93%, Horse: 86%, Human: 100%, Pig: 86%, Rabbit: 93%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against ERCC6L. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ERCC6L

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1250 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ERCC6L

Target: ERCC6L (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6-Like (ERCC6L))

Alternative Name: ERCC6L

Background: ERCC6L is a DNA helicase that acts as an essential component of the spindle assembly checkpoint.ERCC6L contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. ERCC6L acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase.
Alias Symbols: FLJ20105, MGC131695, PICH
Protein Interaction Partner: LMO4, UBC, HTT, BARD1, ACACA, Ercc6l, Plk1, RB1CC1, RPA3,
Protein Size: 1250

Molecular Weight: 141 kDa

Gene ID: 54821

NCBI Accession: NM_017669, NP_060139

UniProt: Q2NKX8