ABCC4 antibody (AA 1-77)
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- Target See all ABCC4 Antibodies
- ABCC4 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4))
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Binding Specificity
- AA 1-77
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ABCC4 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purpose
- Rabbit IgG polyclonal antibody for Multidrug resistance-associated protein 4(ABCC4) detection. Tested with WB in Human.
- Cross-Reactivity (Details)
- No cross reactivity with other proteins.
- Characteristics
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Rabbit IgG polyclonal antibody for Multidrug resistance-associated protein 4(ABCC4) detection. Tested with WB in Human.
Gene Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Protein Name: Multidrug resistance-associated protein 4 - Purification
- Immunogen affinity purified.
- Immunogen
- E.coli-derived human MRP4 recombinant protein (Position: M1-K77).
- Isotype
- IgG
- Top Product
- Discover our top product ABCC4 Primary Antibody
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- Application Notes
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users. - Comment
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Concentration
- 500 μg/mL
- Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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- Target
- ABCC4 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4))
- Alternative Name
- ABCC4 (ABCC4 Products)
- Synonyms
- EST170205 antibody, MOAT-B antibody, MOATB antibody, MRP4 antibody, D630049P08Rik antibody, Mrp4 antibody, ATP binding cassette subfamily C member 4 antibody, multidrug resistance-associated protein 4 antibody, ATP-binding cassette, sub-family C (CFTR/MRP), member 4 antibody, ABCC4 antibody, LOC515333 antibody, LOC616707 antibody, LOC695407 antibody, abcc4 antibody, Abcc4 antibody
- Background
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ABCC4(Atp-binding cassette, subfamily c, member 4), also known as MRP4 or MOATB, is a protein that in humans is encoded by the ABCC4 gene. It belongs to a large family of transmembrane proteins involved in active transport of substrates out of cells. This gene is mapped to chromosome 13q32. ABCC4 acts as an independent regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus. The antiproliferative effect of ABCC4 inhibition was related to cAMP-dependent PKA activation and CREB phosphorylation. Pharmacologic inhibition of ABCC4 activity or knockdown of ABCC4 via RNA interference resulted in reduced migration of DCs from human skin explants and of in vitro-generated Langerhans cells. It has been found that ABCC4 contributes to migration of DCs toward draining lymph nodes and therefore has a role in the initiation of an immune response.
Synonyms: ABCC4 | MOATB | MOAT-B | MRP4 | O15439 - Gene ID
- 10257
- UniProt
- O15439
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