This antibody detects CD229 / LY9 at C-term. At least three isoforms of SLAMF3 are known to exist. This antibody is predicted to not cross-react with other protein family members.
Cross-Reactivity (Details)
Species reactivity (tested):Human, mouse, rat
Purification
Affinity chromatography purified via peptide column
Immunogen
18 amino acid peptide near the carboxy terminus of human CD229
The signaling lymphocyte-activation molecule family member 3 (SLAMF3), also known as LY9 and CD229, is a cell surface receptor that is expressed on T and B lymphocytes and belongs to the CD150/SLAMF1 receptor family. SLAMF3 was identified through a yeast two-hybrid screening in which SLAMF3 bound to the X-linked lymphoproliferative disease gene product SAP, suggesting that in activated T cells, SLAMF3 signaling can be triggered SAP. Its expression on the cell surface appears to be regulated via its interaction with the clathrin-associated adaptor complex 2 (AP-2). Despite its similarity to SLAMF1 in structure and interactions with SAP, SLAMF3-deficient mice do not exhibit phenotypic characteristics associated with SLAMF1- and SAP-deficient mice, suggesting that SLAMF3 plays other roles in T cell activation.Synonyms: Ly-9, Lymphocyte antigen 9, T-lymphocyte surface antigen Ly-9