EFCAB4B antibody (C-Term)

Catalog No. ABIN783785

Product Details anti-EFCAB4B Antibody

Target: EFCAB4B (EF-Hand Calcium Binding Domain 4B (EFCAB4B))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EFCAB4B antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects EFCAB4B at C-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse

Purification: Affinity chromatography purified via peptide column

Immunogen: 14 amino acid peptide near the carboxy terminus of human EFCAB4B

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for EFCAB4B

Target: EFCAB4B (EF-Hand Calcium Binding Domain 4B (EFCAB4B))

Alternative Name: EFCAB4B (EFCAB4B Products)

Synonyms: CRACR2A antibody, Gm1073 antibody, Gm462 antibody, calcium release activated channel regulator 2A antibody, CRACR2A antibody, Cracr2a antibody

Background: EFCAB4B, also known as Calcium release-activated calcium channel regulator 2A, is a novel Ca2+-binding EF-hand protein that is thought to play a key role in store-operated Ca2+ entry in T-cells by regulating CRAC channel activation. EFCAB4B acts as a cytoplasmic calcium-sensor that forms a complex with ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+ concentration. A closely related protein, EFCAB4A, is likely to play a similar role as EFCAB4B, but the detailed function of EFCAB4A is still under investigation.Synonyms: EF-hand calcium-binding domain-containing protein 4B, MGC4266

Gene ID: 84766

NCBI Accession: NP_001138430

UniProt: Q9BSW2