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EFCAB4B antibody

EFCAB4B Reactivity: Human, Mouse, Rat WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7257401
  • Target See all EFCAB4B Antibodies
    EFCAB4B (EF-Hand Calcium Binding Domain 4B (EFCAB4B))
    Reactivity
    • 23
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 21
    • 2
    Rabbit
    Clonality
    • 23
    Polyclonal
    Conjugate
    • 13
    • 2
    • 2
    • 2
    • 2
    • 2
    This EFCAB4B antibody is un-conjugated
    Application
    • 23
    • 13
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Characteristics
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein of human CRACR2A (NP_001138430.1).
    Isotype
    IgG
    Top Product
    Discover our top product EFCAB4B Primary Antibody
  • Application Notes
    WB 1:500-1:2000 IHC 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    EFCAB4B (EF-Hand Calcium Binding Domain 4B (EFCAB4B))
    Alternative Name
    CRACR2A (EFCAB4B Products)
    Synonyms
    CRACR2A antibody, Gm1073 antibody, Gm462 antibody, calcium release activated channel regulator 2A antibody, CRACR2A antibody, Cracr2a antibody
    Background
    Ca2+-binding protein that plays a key role in store-operated Ca2+entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
    Molecular Weight

    Observed_MW: 45 kDa

    Calculated_MW: 45 kDa/83 kDa

    Gene ID
    84766
    UniProt
    Q9BSW2
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