Beclin 1 antibody (Middle Region)

Catalog No. ABIN567417

Product Details anti-Beclin 1 Antibody

Target: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Pig, Dog, Rabbit, Cow, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Beclin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ENLEKVQAEA ERLDQEEAQY QREYSEFKRQ QLELDDELKS VENQMRYAQT

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against BECN1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human BECN1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 450 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-Beclin 1 antibody (ABIN567417)

Lee, Cho, Jung, Tran, Jung, Park, Kim: "Alteration of Phospholipids during the Mitophagic Process in Lung Cancer Cells." in: Journal of microbiology and biotechnology, Vol. 26, Issue 10, pp. 1790-1799, (2016) (PubMed).

Target Details for Beclin 1

Target: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Alternative Name: BECN1 (BECN1 Products)

Synonyms: beclin-1 antibody, atg6 antibody, vps30 antibody, beclin1 antibody, Beclin-1 antibody, becn1 antibody, zgc:73097 antibody, ATG6 antibody, VPS30 antibody, 4921513J16Rik antibody, 5430417M23Rik antibody, Atg6 antibody, beclin 1 antibody, beclin 1, autophagy related antibody, beclin 1 protein antibody, beclin-1 antibody, beclin family protein antibody, beclin 1, autophagy related L homeolog antibody, BECN1 antibody, becn1 antibody, atg6 antibody, CpipJ_CPIJ011087 antibody, PTRG_07825 antibody, SJAG_01876 antibody, Becn1 antibody, becn1.L antibody

Background: BECN1 plays a central role in autophagy. BECN1 may play a role in antiviral host defense. BECN1 protects against infection by a neurovirulent strain of Sindbis virus.
Alias Symbols: ATG6, VPS30, beclin1
Protein Interaction Partner: AMBRA1, PIK3R4, ATG14, CHAF1A, DYNLL1, UVRAG, PIK3CG, PIK3C3, PARK2, DYNC1I1, DAPK1, CDKN2A, BCL2L1, BCL2, BECN1, DACT1, KIAA0226, UBC, RNF2, BRCA1, WASH1, EXOC8, EXOC4, EXOC2, ULK1, ATG3, USP33, S100A8, MCL1, HSPA1A, Vmp1, PYCARD, TAB2, TAB3, GFI1B, ITCH
Protein Size: 450

Molecular Weight: 50 kDa

Gene ID: 8678

NCBI Accession: NM_003766, NP_003757

UniProt: Q14457

Pathways: Autophagy